Portulaca oleracea also provides a source of nutritional benefits owing to its rich omega-3 fatty acids and antioxidant properties. Portulaca oleracea has been used as a folk medicine in many countries, acting as a febrifuge, antiseptic, vermifuge, and so forth.
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EVALUATION OF PORTULACA OLERACEA LINN. FOR HYPOGLYCAEMIC EFFECTS HTML Full Text EVALUATION OF PORTULACA OLERACEA LINN. FOR HYPOGLYCAEMIC EFFECTS Lalromawii* 1, A. Subhalakshmi Devi 2, U. Dhamaraj Meetei 2 and R.K. Bharati Devi 2 Senior Resident, Department of Pharmacology 1, NEIGRIHMS, Shillong, Meghalaya, India Department of Pharmacology 2, RIMS, Imphal, Manipur, India ABSTRACT:Hypoglycaemic and anti-hyperglycaemic effects of Portulaca oleracea Linn. (POL) was evaluated in experimental rat models in vivo.
The aqueous extract of POL was subjected to preliminary toxicity screening by an acute toxicity study in Wister albino rats. The POL was found to be safe in the doses used and there was no mortality up to a dose of 3000mg/kg orally after 24 hours. Hypoglycaemic effects of POL extract with doses 200mg, 400mg and 800mg were evaluated on Wistar albino rats by using a standard protocol.
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Anti-hyperglycaemic effect of POL extract with the same doses i.e. 200mg, 400mg and 800 mg were also studied in alloxan induced diabetic albino rats. The aqueous POL extract at doses 800mg showed significant hypoglycaemic effects as compared with a standard drug like glibenclamide. The same doses of POL also showed anti-hyperglycaemic properties in alloxan induced diabetic rats. The present study showed that the aqueous POL extract has hypoglycaemic as well as anti-hyperglycaemic effects. Keywords: Portulaca oleracea Linn., Aqueous extract, Hypoglycaemic effects, Anti-hyperglycaemic effect INTRODUCTION: Portulaca oleracea Linn. (Portulaceae) is a succulent annual herb, which may reach up to 40cm in height, found abundantly throughout the world and known for its numerous traditional medicinal uses 1, 2.
It is known as Lonika in Sanksrit and Leipak-kundo in Manipuri language. Since time immemorial, the indigenous healers of Manipur use the extract in gonorrhoea, gum and teeth complaints, scurvy and liver diseases. It is also used in kidney and bladder disease, cardiovascular complaints, dysentery, sore nipples and mouth ulcers. The roasted seeds are used as diuretic, anti-dysentery and applied in burns and scalds 3. Chemical extractions have shown it to contain many biologically active compounds like α-linolenic acid and β-carotene, coumarins and monoterpene glycoside, N-transferuloyltyramine, dopamine, DOPA, high concentrations of noradrenaline, ferulic acid and adenosine 4. This traditional medicine has been reported to be having various beneficial pharmacological effects, including antibacterial 5, analgesic, anti-inflammatory 6, skeletal muscle relaxant 7, 8 and wound healing 9, etc.