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Lock and key is an analogy of enzyme catalysis in a cellular reaction. The lock and key are compared directly to the substrate and enzyme, because of the high specificity of their physical shape. Enzymes participate in the reaction they catalyze.

The reactant molecule (substrate) binds to the enzyme molecule at a particular location called the active site. (this is compared to the lock with keyhole) The highly specific nature of an enzyme is due to very precisely defined arrangement of atoms in the active site(again, this is the lock in the analogy). The substrate molecule must have a matching shape (here is the key) that will fit into the active site. The bond breaking and bond forming processes that transform the substrate into products occur while the substrate is bound to the active site of enzyme. Emailchemy 11 serial mac os.

In other words its something like a jigsaw puzzle where the substrate fits into the enzyme. The reaction occurs and the substrate then leaves the enzyme as products. ( Not my work.

Found it on Yahoo Answers.Do not give me credit.Thought I should do this to help people out =] ) Edited answer for readability and clarity - thanks!